Computational Design of Antisense Oligonucleotides

Computational Design of Antisense Oligonucleotides (ASOs)

ASOs are an important class of drugs that function through interfering with mRNA processing through RNase H–mediated degradation, translational arrest, or splicing modulation. Several factors determine the binding efficiency of the ASO to the target sequences. Our robust computational protocol help design efficient ASOs for experimental testing.

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