RNA based therapeutics is gaining rapid attention, since it provides an excellent opportunity for the development of drugs that target pathways involving “undruggable” proteins. This rapidly expanding field offers exciting possibilities for applying structure-based drug design strategies to come up with viable solutions. In this context, computational modelling can provide interesting leads for speeding up the RNA based drug discovery process. At Binary Star, we offer computational solutions to this challenging problem, using a large database of small molecules that have properties specific for binding RNA.